Insulin Resistance: Insulin Action and Its Disturbances in by Sudhesh Kumar, Stephen O'Rahilly

By Sudhesh Kumar, Stephen O'Rahilly

Diabetes is now one of many significant factors of morbidity all over the world. in lots of circumstances, the onset of diabetes is revolutionary, constructing through a of insulin resistance. This ebook considers the advance of this , its results and medical and healing aspects.

The e-book reports the conventional biology of insulin motion on glucose, lipids and proteins. It considers the pathological foundation for insulin resistance in animal versions and people, and discusses the impression of heredity, nutritional elements and workout. medical results together with dyslipidaemia, high blood pressure and polycystic ovary syndrome, and healing recommendations for remedy also are examined.
* offers a professional evaluation of the phenomenon of insulin resistance
* Brings jointly a bunch of contemporary study for the 1st time
* Written via prime specialists in organic and medical researchContent:
Chapter 1 The Insulin Receptor and Downstream Signalling (pages 1–62): Ken Siddle
Chapter 2 Insulin?Mediated rules of Glucose Metabolism (pages 63–85): Daniel Konrad, Assaf Rudich and Amira Klip
Chapter three Insulin motion on Lipid Metabolism (pages 87–103): Keith N. Frayn and Fredrik Karpe
Chapter four The impact of Insulin on Protein Metabolism (pages 105–132): Laura J. S. Greenlund and okay. Sreekumaran Nair
Chapter five Genetically transformed Mouse types of Insulin Resistance (pages 133–153): Gema Medina?Gomez, Christopher Lelliott and Antonio J. Vidal?Puig
Chapter 6 Insulin Resistance in Glucose Disposal and construction in guy with particular connection with Metabolic Syndrome and kind 2 Diabetes (pages 155–178): Henning Beck?Nielsen, Frank Alford and Ole Hother?Nielsen
Chapter 7 significant law of Peripheral Glucose Metabolism (pages 179–206): Stanley M. Hileman and Christian Bjorb?k
Chapter eight courting among fats Distribution and Insulin Resistance (pages 207–235): Philip G. McTernan, Aresh Anwar and Sudhesh Kumar
Chapter nine PPAR? and Glucose Homeostasis (pages 237–267): Robert okay. Semple and Stephen O'Rahilly
Chapter 10 Adipokines and Insulin Resistance (pages 269–295): Daniel okay. Clarke and Vidya Mohamed?Ali
Chapter eleven nutritional components and Insulin Resistance (pages 297–316): Jeremy Krebs and Susan Jebb
Chapter 12 actual job and Insulin Resistance (pages 317–400): Nicholas J. Wareham, Soren Brage, Paul W. Franks and Rebecca A. Abbott
Chapter thirteen Genetics of the Metabolic Syndrome (pages 401–450): George Argyropoulos, Steven Smith and Claude Bouchard
Chapter 14 Insulin Resistance and Dyslipidaemia (pages 451–466): Benoit Lamarche and Jean?Francois Mauger
Chapter 15 Insulin Resistance, high blood pressure and Endothelial disorder (pages 467–483): Stephen J. Cleland and John M. C. Connell
Chapter sixteen Insulin Resistance and Polycystic Ovary Syndrome (pages 485–509): Neus Potau
Chapter 17 Syndromes of critical Insulin Resistance (SSIRs) (pages 511–533): David Savage and Stephen O'Rahilly
Chapter 18 healing innovations for Insulin Resistance (pages 535–560): Harpal S. Randeva, Margaret Clarke and Sudhesh Kumar
Chapter 19 Drug treatment for Insulin Resistance – a glance on the destiny (pages 561–585): Bei B. Zhang and David E. Moller

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Additional resources for Insulin Resistance: Insulin Action and Its Disturbances in Disease

Sample text

9, 394 – 396 It remains to be determined whether these differences arise from subtleties in the way the two receptors utilize common substrates and signalling pathways, or whether there are receptor-specific components that modulate the activity of core pathways. 6 Conclusion The actions of insulin are mediated by a single receptor protein, which is now well characterized. The determinants of specific high affinity ligand binding in the extracellular portion of the receptor are understood in outline if not yet in detail.

The major therapeutic need in relation to insulin action is to mimic or potentiate insulin signalling in diabetes. However, this must be done without simultaneously provoking excessive IGF action, which is increasingly recognized as a contributory factor in cancer progression and metastasis. 9, 394 – 396 It remains to be determined whether these differences arise from subtleties in the way the two receptors utilize common substrates and signalling pathways, or whether there are receptor-specific components that modulate the activity of core pathways.

7, 334, 335 The idea that effective stimulation of GLUT4 vesicle translocation by insulin requires synergistic action of two signals, dependent on PI 3-kinase and TC-10 respectively, is attractive even though the specific molecular targets of either pathway remain to be identified. This hypothesis would help to explain why glucose transport is specifically stimulated by insulin. 122, 336 The specific role of Cbl and Crk in insulin-sensitive tissues may reflect the particular spectrum of binding partners expressed in these tissues (of the many that have been described).

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