Cytochrome P450 by J. B. Schenkman (auth.), Professor John B. Schenkman Ph.D.,

By J. B. Schenkman (auth.), Professor John B. Schenkman Ph.D., Professor Helmut Greim M.D. (eds.)

During this e-book the editors have introduced jointly the widest team of investigators of the cytochrome P450 superfamily so that it will current entire and correct up to date assurance of this crucial enzyme process. The authors describe and learn the parts of the enzyme process, the response mechanisms concerned, and the evolution and nomenclature of this superfamily of enzymes. additionally they describe the hepatic microsomal enzyme in a good number of species, from mammalian to birds and fish, to vegetation and unicellular organisms. different P450 kinds in numerous tissues of the mammalian approach also are handled. Regulatory elements of P450 expression obtain significant recognition, as do reports at the mechanism of interplay of the microsomal monooxygenase procedure parts. Of specific curiosity to the reader are, for the 1st time, a compilation of chapters devoted to types of cytochrome P450 fascinated by steroid hormone biosynthesis. This quantity offers the main entire survey of the cytochrome P450 box. it is going to enable acceptance and knowing of the very huge implications this enzyme procedure has on lifestyles methods.

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Structural Characteristics and Expression of the CYP17 Gene ..... Assumptions About Cytochrome P450c17 Protein Structure . . . Specificity of Ligand Binding. . . . . . . . . . . . . . . . .. Intrinsic and Extrinsic Regulation of Catalytic Properties ......... Cytochrome P450c17 as Target for Suppression of Steroid Hormone Synthesis by Drugs .. . . . . . . . . . . . . . . . . . . . H. The Problem of Cytochrome P450c17 Downregulation: Role of Substrate and Oxygen.

1 Bioi Chern 260:2027-2030 Imai M, Shimada H, Watanabe Y, Malsushima-Higiya Y, Makino R, Koga H, Horiuchi T, Ishimura Y (1989) Uncoupling of the cytochrome P450 cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: a possible role of the hydroxy amino acid in oxygen activation. Proc Natl Acad Sci USA 86:7823-7827 Ishimura Y, Ullrich V, Peterson lA (1971) Oxygenated cytochrome P450 and its possible role in enzymic hydroxylation. Biochem Biophys Res Commun 42:140146 lansson I, Schenkman IB (1987) Influence of cytochrome hs on the stoichiometry of the different oxidative reactions catalyzed by liver microsomal cytochrome P450.

1990). The air-stable semiquinone was also similar to that predicted by QPRIAN and COON (1982) by kinetic studies. These results further demonstrate that the FMN moiety is the high potential flavin and is the semiquinone species present in the air-stable species. III. Kinetics of NADPH·Cytochrome P450 Reductase Reduction In the reductase titration experiments described thus far, a given quantity of reducing equivalents was added to the titration vessel and the absorption spectra recorded after equilibration of the system.

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