Clinical Neuroendocrinology by Luciano Martini (Eds.)

By Luciano Martini (Eds.)

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Clinical Studies with Analogues of LH-RH D-Ala-6-desGly-10-LH-RH EA and D-Leu-6-desGly-10-LH-RH EA were both used for clinical work because of their interesting properties, DAla-6-desGly-10-LH-RH EA was first tested in normal men, and, in doses of 24 Andrew V. , 1974). , 1975). , 1975). , 1976). Extensive clinical tests with D-Leu-6-desGly-10-LH-RH EA are in progress. , 1976), in agreement with results in normal men. , 1975). This is a therapeutically useful route of administration, but the doses required are more than 1000 times larger than those active iv.

1970). J. Med. Chem. 13, 1099-1101. , and Arimura, A. (1974). Brain Res. 80, 165-169. , and Arimura, A. (1975). Acta Endocrinol. (Copenhagen) 80 Suppl. 200, 5-41. Humphrey, R. , Dermody, W. C , Brink, H. , Bousley, F. , Schottin, N. , Vaitkus, J. , Veloso, H. , and Reel, J. R. (1973). Endocrinology 92, 1515-1526. , and McCann, S. M. (1964). Endocrinology 74, 446-452. Immer, H. , Nelson, V. , and Götz, M. (1974). Helv. Chim. Acta 57, 730-734. Iversen, J. (1974). Scand. J. Clin. Lab. Invest. 33, 125-129.

And Arimura, A. (1974c). Biochem. Biophys. Res. Commun. 57, 335-340. Coy, D. , Coy, E. , and Schally, A. V. In "Research Methods in Neurochemistry" (N. Marks and R. , pp. 393^06. Plenum, New York. Coy, D. , Redding, T. , Coy, E. , and Schally, A. V. (1975b). J. Med. Chem. 18, 948-949. Coy, D. , Coy, E. , and Schally, A. V. (1976a). Program 58th Annu. Meet. Am. Endocr. Soc. Abstract No. 305, p. 209. Coy, D. , Vilchez-Martinez, J. , Coy, E. , and Schally, A. V. (1976b). J. Med. Chem. 19, 423-425.

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