Canine Parvovirus: A New Pathogen by Dr. Cherelyn Vella, S. W. Ketteridge (auth.), Dr. Cherelyn

By Dr. Cherelyn Vella, S. W. Ketteridge (auth.), Dr. Cherelyn Vella, S. W. Ketteridge (eds.)

Canine parvovirus (CPV), a brand new virus of the Canidae first seemed in the course of the Seventies, yet illness as a result of this virus was once now not mentioned till 1978. Then inside a number of months the virus crossed nationwide and continental barriers inflicting excessive fatality in pup populations. the same trend of transmission used to be visible in sylvatic dogs yet an infection used to be mostly subclinical. among 1979 and 1981 CPV used to be changed around the globe by way of an antigenic variation distinctive CPV-2a. The epidemiological benefit of this version over CPV isn't really understood. CPV is a brand new pathogen of canines that has attracted a powerful physique of study. even if facets of the biology of this virus stay uncertain, no longer least of that is the questionof its attainable foundation. This booklet offers an up to the moment and accomplished overview of the average historical past of CPV and its keep watch over via prophylactic vaccination. specific cognizance is paid to the concepts used to ascertain the connection among CPV and different parvoviruses. CPV is believed to be a variation of the virulent cat virus FPV (feline parvovirus) and at the least another version is understood MEV (mink enteritis virus). Theories at the genesis of CPV are mentioned. An try to correlate the proof and an hypothetical mechanism during which any such version might have been chosen is out there. This speculation is complemented via serological evidenceof CPV seroconversion in clinically general canines a few years ahead of the virulent pandemic. Many animal parvoviruses are identified and in 1989/1990, at the least 6 new viruses have been defined. CPV could have arisen from an FPV vaccine pressure. using converted dwell vaccines for the regulate of those viruses is puzzled and substitute techniques mentioned. A consise bankruptcy on human parvoviruses describes the ever expanding position of B19 in human disorder, together with that of an opportunistic pathogen in AIDS patients.

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Canine Parvovirus: A New Pathogen

Canines parvovirus (CPV), a brand new virus of the Canidae first seemed through the Nineteen Seventies, yet sickness because of this virus used to be now not stated till 1978. Then inside a couple of months the virus crossed nationwide and continental obstacles inflicting excessive fatality in puppy populations. an identical trend of transmission used to be visible in sylvatic dogs yet an infection used to be mostly subclinical.

Additional resources for Canine Parvovirus: A New Pathogen

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Isolation and properties. J Comp Pathol 79:371 Chanock RM, Lerner RA (eds) (1983) Modern approaches to vaccines: molecular and chemical basis of virulence and immunogenicity. Cold Spring Harbor, New York Cherfas J (1982) Man Made Life. Blackwell, Oxford Clark HF (1978) Rabies viruses increase in virulence when propagated in neuroblastomer cell cultures. Science 199:1072-1075 Clewley JP, Cohen BJ, Field AM (1987) Detection of parvovirus B19 DNA, antigen and particles in the human foetus. J Med Virol 23:367-376 Cockburn A (1947) Infectious enteritis in the Zoological Gardens, Regents Park.

More than 400 CPV isolates collected from several countries across the world were typed. In addition, serum from wild coyotes was examined to determine the natural occurrence of CPV types in unvaccinated canidae (most vaccines were derived from original CPV strains). 28 Vella, Ketteridge The mAbs used were CPV/CPV-2a-specific (mAb7), CPV-specific (mAbs D and J), CPV-2a-specific (mAb IDI), CPVIFPVIMEV reacting (mAb F), and FPV-specific (mAb H). This study revealed a rapid global replacement of the original virus by CPV-2a in domestic dogs between 1979 and 1982.

Canine Parvovirus: A New Pathogen 47 Acknowledgements. The authors are indebted to Dr. Desmond McCarthy (Queen Mary and Westfield College) for his helpful discussions and critical reading of the manuscript. We would also like to thank Dr. Barry Bush (Royal College of Veterinary Surgeons) for his valuable help. The encouragement and guidance given by Michael Gordon, John Madley (Glaxovet Limited) and Dr. B. J. Cohen (Central Public Health Laboratory, Colindale) are also gratefully acknowledged. References Abinati FR, Warfield MS (1961) Recovery of a haemadsorbing virus (HADEN) from the gastrointestinal tract of calves.

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