Applications of fuzzy logic in bioinformatics by Dong Xu, James M Keller, Mihail Popescu, Rajkumar Bondugula

By Dong Xu, James M Keller, Mihail Popescu, Rajkumar Bondugula

Many organic platforms and gadgets are intrinsically fuzzy as their houses and behaviors include randomness or uncertainty. furthermore, it has been proven that particular or optimum tools have major obstacle in many bioinformatics difficulties. Fuzzy set conception and fuzzy good judgment are excellent to describe a few organic systems/objects and supply solid instruments for a few bioinformatics difficulties. This publication comprehensively addresses a number of very important bioinformatics subject matters utilizing fuzzy ideas and ways, together with size of ontological similarity, protein constitution prediction/analysis, and microarray information research. It additionally reports different bioinformatics functions utilizing fuzzy recommendations.

Contents: advent to Bioinformatics; creation to Fuzzy Set idea and Fuzzy common sense; Fuzzy Similarities in Ontologies; Fuzzy common sense in Structural Bioinformatics; software of Fuzzy good judgment in Microarray info Analyses; different functions; precis and Outlook.

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Computational proteomics handles management and analysis of proteomics data for protein identification and protein interaction determination. Computational systems biology addresses algorithm and application development for systems biology. On the application side, sub-disciplines focus on the application of bioinformatics in different biological subjects. For example, immunoinformatics models immunological components for better understanding immune functions. Pharmacoinformatics deals with drug discovery using bioinformatics approaches.

The journal Fuzzy Sets and Systems published a “40th Anniversary of Fuzzy Sets” in December 2005 that contains 14 position papers covering various aspects of the role and future prospects of fuzzy sets [Dubois, 2005]. The mathematical basis for formal fuzzy logic can be found in infinite-valued logics, first studied by the Polish logician Jan Lukasiewicz in the 1920s (see [Borkowski, 1970]). Lukasiewicz constructed a series of multi-valued logical systems, generalizing from small finite numbers of truth-values to those containing infinite sets of truth values.

42 Applications of Fuzzy Logic in Bioinformatics The system of inference described above is referred to as a MamdaniAssilion or MA fuzzy rule system [Mamdani, 1977]. An alternate formulation, denoted as a Takagi-Sugeno-Kang (TKS) system [Takagi and Sugeno, 1985; Sugeno and Kang, 1988] only modifies the membership functions in the consequent clause. It was developed for control applications where the output of the rule firing should be a function of the set of crisp input values. Instead of a general fuzzy set B of Y, the output of each rule is a specific function of the real inputs.

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