By Steven S. M. Chin, Ronald K. H. Liem (auth.), George Perry (eds.)
The neuronal cytoskeleton is a posh constitution conscious of either intrinsic and extrinsic elements. outlined populations of neurons within the brains of sufferers with Alzheimer and a number of other neurodegenerative illnesses include irregular filamentous accumulations which proportion components with the cytoskeleton. even supposing there's a common consensus that those irregular filaments do include cytoskeletal components, a lot debate is still relating to which cytoskeletal parts are included and no matter if the cytoskeletal rearrangement is fundamental or secondary to different mobile adjustments. during this publication those questions are addressed in a historic perspect ive in mild of recent information that enables the reinterpretation of formerly pronounced effects. Contributions are according to a number of the significant tech niques of contemporary biology together with biochemistry, molecular biology, electron microscopy and immunocytochemistry. within the view of the editor, this quantity is being written at a time whilst our knowing of the cytopathology of Alzheimer ailment is relocating from predominantly descriptive to either analytical and mechanistic. i'm hoping that this contribution will offer impetus to hurry this transi tion. George Perry Cleveland, Ohio vii ACKNOWLEDGEMENT The help of the Fidia Pharmaceutic company for the pc generated colour determine on web page sixty five is gratefully acknowledged.
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Extra info for Alterations in the Neuronal Cytoskeleton in Alzheimer Disease
Further, the phosphorylation of tau may affect interactions, perhaps even when it is incorporated into microtubules. For example, it was reported 26 that phosphorylation (unidentified mode) decreased the effect of tau on actin gelation. Whatever particular effects are ultimately found to be relevant, the occurrence of two modes of phosphorylation along with the existence of substantial amounts of nonphosphorylated tau in vivo, point toward a dynamic regulatory system with diverse effects. References 1.
12. 13. 14. 15. 16. 17. 18. 19. 20. 21. N. Nukina and Y. Ihara, One of the antigenic determinants of paired helical filaments is related to tau protein. J Biochem. 99: 1541-1544 (1986). I. , Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. ,T Biol Chem. 261: 6084-6089 (1986). S. L. J. Selkoe, Microtubule-associated protein tau (t) is a major antigenic component of paired helical filaments in Alzheimers disease. Proc Natl Acad Sci USA 83: 4044-4048 (1986). D.
J Immunol 111:24-26, 1973. 10. Glenner GG, Ein D, Eanes ED, et al: Creation of "amyloid" fibrils from Bence Jones proteins in vitro. Science 174:712-714, 1971. 11. Franklin Ee, Pras M, Levin M, et a1: The partial amino acid sequence of the major low molecular weight component of two human amyloid fibrils. FEBS Lett 22:121-123, 1972. 12. Pras M, Franklin EC, Shibolet S, et al: Amyloidosis associated with renal cell carcinoma is of the AA type. Am J Med 73:426-428, 1982. 13. Sohar E, Gafni J, Pras M, et al: Familial Mediterranean Fever: A survey of 470 cases and review of the literature.